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KMID : 0861020030180040235
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Korea Journal of Herbology
2003 Volume.18 No. 4 p.235 ~ p.243
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Chemical Structure and Isolation of Novel Anti-Hypertensive Ingredient as Condensed Tannin from the pods of Korean Caesalpinia sepiaria
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Abstract
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Objectives : The study was investigated decrease effiency for blood pressure of the pods of Caesalpinia sepiaria
Methods : We isolated an novel compound as an angiotensin converting enzyrne(hrpertensive enzyme) inhibitor from the pods of Caedpinia sepiaria We measured inhibition rate of angiotensin converting enzyme.
Results : We decided chemical structure of this new material, prodelphinidin B-3 3-0-gallate that combined with (+)-gallocatechin-3-O-gallate and (+)-gallocatechin by mechanical analysis. Effect of inhibition on the angiotensin converting enzyme was shown that B-ring, gallate compound in prodelphinidins, grown the effect of inhibition. Frodelphinidin B-3 3-0-gallate inhibited about 75.5% at 75 μmole, is shown a possibility that is used to industry.
Conclusion : The pods of Chsalpinia sepiaria were expected functional agents for decreasing blood pressure at drug and food industry.
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